{"product_id":"neoxidina-alcolica-disinfettante-spray-250ml","title":"NEOXIDINA ALCOHOL DISINFECTANT SPRAY 250ml","description":"\u003cp\u003e\u003cstrong\u003eNEOXIDINA ALCOLICA INCOLORE 250 ML.\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003eSurgical Medical Device, Intact Skin (Chlorhexidine gluconate)\u003cbr\u003e\u003cstrong\u003eReady-to-use hydroalcoholic solution\u003c\/strong\u003e (EXTERNAL USE)\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eComposition\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e100 g of solution contain:\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eActive ingredients:\u003c\/strong\u003e\u003cbr\u003eChlorhexidine gluconate 0.50g\u003cbr\u003eEthyl alcohol: 66.29g\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eExcipients:\u003c\/strong\u003e\u003cbr\u003eGlycerin (F.U.): 0.50g\u003cbr\u003eMyristyl alcohol: 1.50g\u003cbr\u003eAlcohol denaturants, purified water q.s. to: 100.00g\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eProduct Presentation (chemical - physical characteristics)\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eNeoxidina Alcolica Incolore\u003c\/strong\u003e is a ready-to-use alcoholic solution for the antisepsis of intact skin and hands.\u003cbr\u003eIt contains chlorhexidine digluconate and ethyl alcohol.\u003cbr\u003eIt has excellent skin tolerability; even after prolonged use, hands remain soft and smooth, thanks to the presence of particular emollient and superfatting substances (glycerin and myristyl alcohol), which prevent epidermal cracking, promote the regeneration of the lipid component of the skin, and restore physiological pH.\u003cbr\u003eIt has an immediate and prolonged action over time.\u003cbr\u003eThe recent guidelines of the American CDC suggest the use of alcohol solutions for social and surgical antisepsis of the hands, as their use, unlike antiseptic soaps, does not require water, and is easy and quick.\u003cbr\u003eWith the addition of emollients, these alcohol solutions show greater skin tolerability compared to antiseptic liquid soaps in which the use of dermoprotective ingredients has little effectiveness.\u003cbr\u003e\u003cbr\u003eToxicological data related to chlorhexidine are reported below:\u003cbr\u003e• Acute chlorhexidine toxicity\u003cbr\u003eAcute toxicity studies after oral, intravenous and subcutaneous administration were conducted on rats and mice. The results obtained are summarized as follows:\u003cbr\u003e• oral route: 1260-1950 mg\/kg\u003cbr\u003e• subcutaneous route: 637-632 mg\/kg\u003cbr\u003e• intravenous route: 18-13 mg\/kg\u003cbr\u003e• Chronic chlorhexidine toxicity\u003cbr\u003eIn rats, chronic oral exposure for 2 years to chlorhexidine solutions at doses of 5, 25 and 40 mg\/kg\/day showed that chlorhexidine is not carcinogenic.\u003cbr\u003eIn these animals, reactive histiocytosis of the mesenteric lymph nodes was observed: this phenomenon, however, did not have a progressive character during the two years of observation and showed regression upon discontinuation of treatment.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eChemical-physical characteristics of Neoxidina Alcolica Incolore:\u003c\/strong\u003e\u003cbr\u003eAppearance: Clear solution;\u003cbr\u003eColor: Colorless;\u003cbr\u003eSpecific gravity:\u003cbr\u003eUnit of measure: g\/ml at 20 °C;\u003cbr\u003eStandard values: 0.865 - 0.885;\u003cbr\u003eChlorhexidine assay:\u003cbr\u003eUnit of measure: % w\/w;\u003cbr\u003eStandard values: 0.48 – 0.52.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eField and method of use\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eNeoxidina Alcolica Incolore\u003c\/strong\u003e is very practical to use as it does not require the addition of water for washing or rinsing; skin and hand antisepsis can, therefore, be carried out anywhere, regardless of the presence of sponges and water.\u003cbr\u003e\u003cstrong\u003eNeoxidina Alcolica Incolore\u003c\/strong\u003e can be used in all departments where hygiene is important, such as hospital wards, operating rooms, intensive care units, ambulances, diagnostic clinics, and others, i.e., for antisepsis:\u003cbr\u003e\u003cbr\u003ea) \u003cstrong\u003eof the patient's intact skin\u003c\/strong\u003e before surgical interventions or other invasive maneuvers;\u003cbr\u003eb) \u003cstrong\u003eof the hands\u003c\/strong\u003e of healthcare personnel for the implementation of antiseptic procedures, after contact with infected materials and in surgical preparation.\u003cbr\u003eThe product should be used as is, without dilution.\u003cbr\u003ea)\u003cstrong\u003eAntisepsis of the patient's intact skin:\u003c\/strong\u003e impregnate a sterile swab and pass it over the area to be treated, rubbing vigorously for at least two minutes.\u003cbr\u003eb) \u003cstrong\u003ePre-surgical hand antisepsis:\u003c\/strong\u003e\u003cbr\u003e• dispense 6 ml (3 strokes of the 2 cc dispenser pump) of solution onto hands and forearms;\u003cbr\u003e• rub vigorously for at least 3 minutes or until completely dry;\u003cbr\u003e• repeat the operation a second time.\u003cbr\u003ec) \u003cstrong\u003eHand antisepsis for healthcare personnel in the ward:\u003c\/strong\u003e\u003cbr\u003e• dispense and spread 4 ml (2 strokes of the 2 cc dispenser pump) of solution onto hands and wrists;\u003cbr\u003e• rub vigorously for at least 30 seconds and wait until completely dry;\u003cbr\u003e\u003cbr\u003eIt should be emphasized that, before starting hand antisepsis operations, or later when hands are visibly dirty, it is necessary to wash them with an antiseptic detergent solution.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eMechanism of action and germicidal activity:\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eNeoxidina Alcolica Incolore\u003c\/strong\u003e is a solution based on chlorhexidine digluconate and ethyl alcohol.\u003cbr\u003e\u003cstrong\u003eChlorhexidine gluconate\u003c\/strong\u003e is particularly active against Gram-positive germs, yeasts, and viruses.\u003c\/p\u003e\u003cp\u003eThe action is attributable to an inactivation of the fundamental enzymatic systems of the cell wall, initial disorganization of the cytoplasmic membrane, modification of permeability, and consequent loss of cellular material.\u003cbr\u003e\u003cstrong\u003eEthyl alcohol\u003c\/strong\u003e has excellent in vitro germicidal activity against Gram-positive and Gram-negative bacteria, including drug-resistant pathogens (e.g., MRSA and VRE), mycobacteria, and yeasts.\u003cbr\u003eThe rapid biocidal action is attributable to its ability to denature, in the presence of water, the proteins of the cytoplasmic membrane.\u003cbr\u003eAs demonstrated by specific biocidal activity studies, \u003cstrong\u003eNeoxidina Alcolica Incolore\u003c\/strong\u003e effectively reduces the resident and transient bacterial flora of the skin.\u003cbr\u003eThe solution has bactericidal (Gram + and Gram - bacteria), fungicidal (Candida albicans), and virucidal activity.\u003cbr\u003e\u003cbr\u003eThe biocidal efficacy data of the product \u003cstrong\u003eNeoxidina Alcolica Incolore\u003c\/strong\u003e are summarized in the following tables.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTable 2: Basic bactericidal activity (EN 1040: 1997) - Contact time = 30 seconds\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eMicroorganism group:\u003c\/strong\u003e Gram + bacteria\u003cbr\u003e\u003cstrong\u003eSpecific strain:\u003c\/strong\u003e Staphylococcus aureus ATCC 6538\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e5\u003c\/sup\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eMicroorganism group:\u003c\/strong\u003e Gram - bacteria\u003cbr\u003e\u003cstrong\u003eSpecific strain:\u003c\/strong\u003e Pseudomonas aeruginosa ATCC 15442\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e5\u003c\/sup\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eMicroorganism group:\u003c\/strong\u003e Acid-resistant bacilli\u003cbr\u003e\u003cstrong\u003eSpecific strain:\u003c\/strong\u003e Mycobacterium terrae ATCC 15755\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e5\u003c\/sup\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eTable 3: Bactericidal activity in suspension for hygienic and surgical hand rubbing (prEN 12054: 1995)\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e- Contact time = 30 seconds\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eMicroorganism group:\u003c\/strong\u003e Gram + bacteria\u003cbr\u003e\u003cstrong\u003eSpecific strain:\u003c\/strong\u003e\u003cbr\u003eEnterococcus hirae ATCC 10541\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e4\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eStaphylococcus aureus ATCC 6538\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e4\u003c\/sup\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eMicroorganism group:\u003c\/strong\u003e Gram - bacteria\u003cbr\u003e\u003cstrong\u003eSpecific strain:\u003c\/strong\u003e\u003cbr\u003eEscherichia coli K12 NCTC 10538\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e4\u003c\/sup\u003e\u003cbr\u003ePseudomonas aeruginosa ATCC 15442\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e4\u003c\/sup\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eBactericidal activity under simulated practical conditions of use (EN 1500: 2000) - Contact time = 30 seconds\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eMicroorganism group:\u003c\/strong\u003e Gram - bacteria\u003cbr\u003e\u003cstrong\u003eSpecific strain:\u003c\/strong\u003e Escherichia coli K12 NCTC 10538\u003cbr\u003e\u003cstrong\u003eAverage logarithmic reduction:\u003c\/strong\u003e 3.96\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eBasic fungicidal activity (EN 1275: 1999) - Contact time = 30 seconds\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eMicroorganism group:\u003c\/strong\u003e Yeasts\u003cbr\u003e\u003cstrong\u003eSpecific strain:\u003c\/strong\u003e Candida albicans ATCC 10231\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e4\u003c\/sup\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eVirucidal activity - Contact time = 30 seconds\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eVirus tested:\u003c\/strong\u003e HBV\u003cbr\u003e\u003cstrong\u003eTest type:\u003c\/strong\u003e MADT test\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e3\u003c\/sup\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eVirus tested:\u003c\/strong\u003e HCV\u003cbr\u003e\u003cstrong\u003eTest type:\u003c\/strong\u003e Inhibition of viral binding to VERO cells\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e3\u003c\/sup\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eVirus tested:\u003c\/strong\u003e HIV\u003cbr\u003e\u003cstrong\u003eTest type:\u003c\/strong\u003e Inhibition of infectivity on sensitive cells\u003cbr\u003e\u003cstrong\u003eReduction:\u003c\/strong\u003e \u0026gt; 10\u003csup\u003e4\u003c\/sup\u003e\u003cbr\u003e\u003cbr\u003eFurthermore, the product has been tested, according to the protocol defined by standard prEN 14476:\u003cbr\u003e2002, against a strain of \u003cstrong\u003eRotavirus\u003c\/strong\u003e.\u003cbr\u003eThe results obtained demonstrate that \u003cstrong\u003eNeoxidina Alcolica Incolore\u003c\/strong\u003e is effective against this specific viral strain in 30 seconds under clean conditions, and in 1 minute under dirty conditions.\u003cbr\u003e\u003cbr\u003eAll primary packaging is manufactured from high-density polyethylene (HDPE) according to the technical specifications provided by the European Pharmacopoeia.\u003cbr\u003eThis material does not contain latex and is perfectly compatible with all components of the formulation.\u003c\/p\u003e","brand":"FARMEC","offers":[{"title":"Default Title","offer_id":57720092557657,"sku":"UWSPGB","price":9.24,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/0043\/6980\/files\/magBarmonia_20173-17922-whatsapp_image_2026-04-02_at_15.jpg?v=1775138931","url":"https:\/\/armoniashop.com\/en\/products\/neoxidina-alcolica-disinfettante-spray-250ml","provider":"ArmoniaShop.com","version":"1.0","type":"link"}